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Hydroxyapatite is a material of great interest in dentistry today due to its natural similarity to the mineral composition of human teeth and bones. It plays a significant role in remineralizing tooth enamel, helping to repair early cavities and strengthen teeth against decay. Unlike fluoride, hydroxyapatite directly integrates with enamel, filling microscopic defects and improving surface smoothness. It also offers biocompatibility, making it safe for patients, including children and those with fluoride sensitivities. Industry expert Anne O. Rice, BS, RDH, CDP, FAAOSH explores the history, benefits, and possibilities of hydroxyapatite in the following articles.